Gastrointestinal: Advanced assays for gastric and colorectal cancer, lymphoproliferative disorders, and celiac disease

Advanced assays for gastric and colorectal cancer, lymphoproliferative disorders, and celiac disease

  • K-ras and BRAF mutations
  • Microsatellite instability (MSI) by PCR and MLH1/MSH2/MSH6 by IHC
  • HER-2 expression by IHC and PCR
  • Chromosome 18q allelic loss (18q loss of heterozygosity)
  • Circulating tumor cells
  • Dihydropyrimidine dehydrogenase (DPD) for 5-fluoracil toxicity
  • UGT1A1 genotype
  • Flow cytometry and IHC for GI lymphoproliferative disorders
  • Antibody screening and HLA-DQ genotyping for celiac disease